Gondomono (Hedycium Spicatum) Ethanol Exstract Anti-Proliferation, Apoptosis and P53 Cancer Cell Line

Nur Rahman Nur Rahman


The incidence of cancer from year to year continues to increase. Some of the causes of this incident include an unhealthy lifestyle, smoking, a diet high in fat and low in fiber. The Gondomono plant (hedychium spicatum) are the most studied species. Interesting compounds have been identified like coronarin D, which possesses antibacterial, antifungal and antitumor activities, as well as isocoronarin D, linalool and villosin that exhibit better cytotoxicity towards tumor cell lines than the reference compounds used, with villosin not affecting the non-tumor cell line. This study aims to obtain scientific evidence that Gondomono extract (hedychium spicatum) is proven to be anti-cancer. The impact obtained will be utilized by local Indonesian plants that can be processed or produced as functional food and herbal medicine for anti-cancer bioactivity toxicity with various tests including the making gondomono (hedycium spicatum) flour, ethanol extraction method, insilico analysis and Gas Chromatography-Mass Spectrometry (GC-MS) analysis, then the second stage test, namely the MTT test, P53 test and apoptosis test.

Keywords: gondomono; hedycium spicatum; anti-proliferasi; cancer cell line


Alison MR, 2001. Cancer. Imperial College School of Medicine, London, UK Encyclopedia Of Life Sciences. Nature Publishing Group / www.els.net.

Jemal A, Freddie Bray, Melissa M. Center, Ferlay J,Ward E, Forman , 2011. Global Cancer Statistics. American Cancer Society.

Heron M, 2012. Deaths: Leading Causes for 2008. National Vital Statistics Reports.Volume 60, Number 6 June 6, 2012.

Riskesdas. Badan Penelitian Dan Pengembangan Kesehatan Kementerian Kesehatan RI Tahun 2010. 2010.

WHO. 2008. Policy and Advocacy.(Cancer control : knowledge into action : WHO guide for effective programmes ; module 6.)5.Guidelines. I.World Health Organization. II.Series.

Donaldson MS, 2004. Nutrition and cancer: A review of the evidence for an anti-cancer. Diet. Nutrition Journal 2004, 3: Nutrition Journal.

Wetwitayaklung P., T. Phaechamud and Keokitichai, 2005, The Antioksidan Activity of Caesalpinia sappan L., Heartwood in Various Ages. Naresuan University Journal, 13(2), pp.43-52..

Amador et al. 2007 . Alkaloids in solanum torvum sw (solanaceae) (With 2 Tables & 1Figure) artículos originals.

Narwanto, M.I., dkk (2018). Identifikasi dan Uji In Silico Potensi Anti Inflamasi Dan Antioksidan Senyawa Polifenol Ekstrak Metanol Biji Tamarindus indica. Journal of Agromedicine and Medical Sciences. Vol. 4 No. 1 (2018).

Yuhendri., dkk (2012). Isolasi Dan Uji Toksisitas Metabolit Sekunder Ekstrak N-Heksana Kulit Batang Tumbuhan Polyalthia Pulchra Var. Angustifolia King (Annonaceae). Jurnal. Kampus Binawidya Pekanbaru.

Mosmann, 1983, Rapid Colorimetric Assay for Celluler Growth and Survival: Applicaton to Proliferation and Cytotoxicity Assay, DNA X Research Intitute of Molekular and Cellular Biology, Inc. USA.

Wahyuni, S., dkk. (2006). Aktivitas Anti Kanker Senyawa=Senyawa Kitooligomer. Jurnal Teknol dan Industri Pangan, Vol. XVII No. 1 Tahun 2016.

Dahab A R dan Fatma Afifi 2007. Antiproliferative activity of selected medicinal plants of Jordan against a breast adenocarcinoma cell line (MCF7).Scientia Pharmaceutica. 75: 121-136.

Chemoprevention Research Center (CCRC) Fakultas Farmasi UGM.

Kwan, Y. P., Saito, T., Ibrahim, D., Al-hassan, F. M. S., Oon, C. E., Chen, Y., … Sasidharan, S. (2015). Evaluation of the cytotoxicity , cell-cycle arrest , and apoptotic induction by Euphorbia hirta in MCF-7breast cancer cells. Pharmaceutical Biology, 0(0), 1–14. https://doi.org/10.3109/13880209.2015.1064451


  • There are currently no refbacks.

Copyright (c) 2021 Nur Rahman Nur Rahman

"HEALTH NOTIONS" ISSN: 2580-4936 (online version only), published by Humanistic Network for Science and Technology    

Cemara street 25, 001/002, Dare, Ds./Kec. Sukorejo, Ponorogo, East Java, Indonesia, 63453